A non-contact knee injury suffered by Arizona Cardinals quarterback Kyler Murray forced him to leave the field after the game.
According to Rapoport, Murray is expected to undergo an MRI and other tests eventually, to determine whether he has sustained a serious injury.
Kliff Kingsbury said the Cardinals would know more in the morning after their 27-13 loss to the New England Patriots.
In the third play from scrimmage, Murray scrambled to get his feet underneath him, but he went down.
As soon as his condition was determined as questionable to return to duty, he was ruled out shortly afterward due to the grim nature of the scene.
Murray was surrounded by teammates and was seen with tears in his eyes as he was transported off the field and covered his head with a towel before being replaced by Colt McCoy.
Murray is in his fourth season as a pro bowler, but he's missed two games due to hamstring injuries and three due to ankle surgery last year.
The scenario on Monday was much different and worrisome than the previous two as he finished both games before missing time.